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Rapamycin inhibits mTOR/P70S6K signaling suppressed VSMC dedifferentiation. VSMCs were treated with PDGF-BB (20 ng/mL) for 24 h. A. MTT assay was used to assess the proliferation of VSMCs. B. Wound-healing assay was performed to evaluate migration in VSMCs. C. Transwell assay was carried out to assess the invasion ability of VSMCs. D, E. Western blotting was applied to quantitate the expression of contractile proteins (*P<0.05 vs treatment with PDGF-BB alone; n=3).
