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. 2014 Jul 25;4:5831. doi: 10.1038/srep05831

Figure 2. TLR7 activated by imiquimod induced ectopic expression of K17 and stimulated interfollicular cell proliferation.

Figure 2

(A–F) Immunohistochemistry staining for K17 highlighted its expression pattern in epidermis. Arrowheads indicated the ectopic expression of K17 in A and C. (G–L) Immunohistochemistry with the proliferation associated marker PCNA showed the proliferative epidermal cells. Black dashed lines outlined the epidermal region. Imiquimod treated skin (G); Imiquimod and IRS661 treated skin (H); Imiquimod and control ODN treated skin (I); DMSO treated skin (J); DMSO and IRS661 treated skin (K); DMSO and control ODN treated skin (L). IFE, interfollicular epidermis. (M) Quantification of the proliferation of interfollicular cells in G–L. **: P < 0.01, t-test.