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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Curr Signal Transduct Ther. 2011;6(3):428–440. doi: 10.2174/157436211797483930

Fig. (3).

Fig. (3)

The TRL2 pathway is activated by Tollip and results in IRAK suppression. Upon stimulation with IL-1, the Tollip-IRAK-1 complex is recruited to the IL-1 receptor complex causing IRAK-1 phosphorylation, dissociation from Tollip and TRAF6 activation. Tollip overexpression leads to the suppression of NF-kβ inhibition. Negative regulation of TLR signaling by Tollip may therefore serve to limit the production of pro-inflammatory mediators during the inflammation process following an infection.