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. 2017 Mar 27;10:69–78. doi: 10.2147/PGPM.S107047

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© 2017 Umerez et al. This work is published and licensed by Dove Medical Press Limited

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MTX pathway.

Note: MTX and its metabolites are indicated.

Abbreviations: ABCs, ABC family transporters; DHF, dihydrofolate; DHFR, dihydrofolate reductase; MTHFR, methylenetetrahydrofolate reductase; MTX, methotrexate; MTXPG, methotrexate polyglutamated forms; RFC1, reduced folate carrier; SHMT1, serine hydromethyl transferase; SLCs, SLC family transporters; THF, tetrahydrofolate; TS, thymidilate synthase; 5-CH-THF, 5-methyltetrahydrofolate; 5,10-CH2-THF, 5,10-methylenetetrahydrofolate.