Table 2. Prioritized Drug Targets: Ranking putative drug targets from targetTB H-list, based on the number of connections to approved drugs from the databases used in this study. The description of each protein along with its clustering coefficient (CC) value in the bipartite network has been listed. The essentiality inference of the targets obtained from Ghosh et.al 2013, has also been indicated, these include (A) Microarray analysis, (B) Flux balance analysis, (C) Protein-protein interaction analysis, (D) Phyletic retention analysis and (E) Transposon hybridization experiments.

Protein	Gene Name	CCbp	Essentiality Inference	Protein Description
Rv2158c	murE	0.77	A; B; C; D; E	ProbableUDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE
Rv2842c	Rv2842c	0.72	A	Conserved hypothetical protein
Rv3303c	lpdA	0.71	A; D; E	NAD(P)H quinone reductase LpdA
Rv2335	cysE	0.66	A; B; C; E	Probable serine acetyltransferase CysE (sat)
Rv2398c	cysW	0.63	A; D; E	Probable sulfate-transport integral membrane protein ABC transporter CysW
Rv2689c	Rv2689c	0.61	A; D	Conserved alanine and valine and glycine rich protein
Rv3139	fadE24	0.59	A; D; E	Probable acyl-CoA dehydrogenase FadE24
Rv2935	ppsE	0.58	A; B	Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Rv2026c	Rv2026c	0.58	A; D; E	Conserved hypothetical protein
Rv0914c	Rv0914c	0.55	A; D	Possible lipid carrier protein or keto acyl-CoA thiolase
Rv3343c	ppe54	0.52	A; E	PPE family protein PPE54
Rv2388c	hemN	0.52	A; B; C; D	Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase)
Rv0542c	menE	0.48	A; C; D; E	Possible O-succinylbenzoic acid--CoA ligase MenE (OSB-CoA synthetase) (O-succinylbenzoate-CoA synthase)
Rv3245c	mtrB	0.48	A; D; E	Two component sensory transduction histidine kinase MtrB
Rv2900c	fdhF	0.46	A	Possible formate dehydrogenase H FdhF (formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide) (formate dehydrogenase-H alpha subunit) (FDH-H)
Rv0220	lipC	0.45	A; D	Probable esterase LipC
Rv1220c	Rv1220c	0.45	A	Probable methyltransferase
Rv3801c	fadD32	0.43	A; B; D; E	Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity.
Rv1613	trpA	0.43	A; B; E	Probable tryptophan synthase, alpha subunit TrpA
Rv2573	Rv2573	0.42	A; B; C; E	Conserved hypothetical protein
Rv2678c	hemE	0.42	A; B; C; E	Probable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD)