| Atazanavir (DB01072;DR7) |
1 |
Rv2026c; Rv2335; Rv1220; Rv2935 |
Used in combination with other antiretroviral agents for the treatment of HIV-1 infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission. |
| Indinavir (DB00224;MK1) |
0.95 |
Rv2158c; Rv2026; Rv2335; Rv2842c; Rv1220c; Rv2689c; Rv2935 |
Indinavir is an antiretroviral drug for the treatment of HIV infection. |
| Lopinavir (DB01601;AB1) |
0.86 |
Rv0542c; Rv1663; Rv2678c; Rv2842c; Rv2689c; Rv2935 |
Indicated in combination with other antiretroviral agents for the treatment of HIV-infection |
| Saquinavir (DB01232;ROC) |
0.81 |
Rv2158c; Rv0904c; Rv2026c; Rv3303c; Rv2510c; Rv0627; Rv1663; Rv2335; Rv2946c; Rv2996c; Rv2678c; Rv2842c; Rv0237c; Rv1220c′ Rv2689c; Rv1505c; Rv2935; Rv2931 |
For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues. |
| Nelfinavir (DB00220;1UN) |
0.77 |
Rv0237; Rv1663; Rv1843c; Rv2026c; Rv2678c; Rv2689c; Rv2842c; Rv2935; Rv3303c; Rv3882c |
Used in combination with other antiviral drugs in the treatment of HIV in both adults and children |
| Nilotinib (DB04868;NIL) |
0.7 |
Rv0237; Rv1663; Rv1843c; Rv2026c; Rv2678c; Rv2689c; Rv2842c; Rv2935; Rv3303c; Rv3882c; |
For the potential treatment of various leukemias, including chronic myeloid leukemia (CML) |
| Tipranavir (DB00932;TPV) |
0.69 |
Rv0555; Rv0904c; Rv1127c; Rv1550; Rv1663; Rv2026c; Rv2153c; Rv2388c; Rv2678c; Rv2689c; Rv2726c; Rv3825c; Rv3883c; Rv3886c; |
For combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors |
| Ritonavir (DB00503;RIT) |
0.68 |
Rv0511; Rv0627; Rv0904c; Rv1092c; Rv1220c; Rv1237; Rv1663; Rv1843c; Rv2026c.; Rv2335; Rv2388c; Rv2678c; Rv2689c; Rv2842c; Rv2935; Rv3303c; Rv3509c; Rv3582c; Rv3825c; Rv3886c; |
Indicated in combination with other antiretroviral agents for the treatment of HIV-infection. |
| Rosiglitazone (DB00412;BRL) |
0.66 |
Rv0755c; Rv1753c; Rv1886c; Rv3804c; |
For the treatment of Type II diabetes mellitus |
| Amprenavir (DB00701;478) |
0.64 |
Rv0085; Rv0237; Rv0478; Rv0635; Rv1127c; Rv1237; Rv1505c; Rv1542c; Rv1655; Rv1663.2; Rv1843c; Rv1850; Rv2153c; Rv2524c; Rv2524c; Rv2613c; Rv2689c; Rv2931; Rv2938; Rv2939; Rv3135; Rv3245c; Rv3804c; Rv3882c; Rv3883c; Rv3886c; Rv3887c; |
For the treatment of HIV-1 infection in combination with other antiretroviral agents. |
| Gefitinib (DB00317;IRE) |
0.61 |
Rv0085; Rv0291; Rv1287; Rv1836c; Rv2156c; Rv2296; Rv2869c; Rv2889c; Rv3737; |
For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies. |
| Tamoxifen (DB00675;CTX) |
0.61 |
Rv0228; Rv0237; Rv0290; Rv0527; Rv0545c; Rv1650; Rv1836c; Rv2281; Rv2439c; Rv2678c; Rv2986c; Rv3722c; Rv3737; |
For the treatment of breast cancer. |
| Dasatinib (DB01254;1N1) |
0.61 |
Rv2069; Rv2202c; Rv2231c; Rv2727c; Rv3372; Rv3886c; |
For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. |
| Darunavir (DB01264;017) |
0.6 |
Rv0542c; Rv1237; Rv1409; Rv1663; Rv2026c; Rv2153c; Rv2158c; Rv2613c; Rv2678c; Rv2689c; Rv2842c; Rv2897c; Rv2935; Rv3255c; Rv3825c; Rv3886c; |
Darunavir, co-administered with ritonavir, and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor. |
| Adenosine (DB00640;ADN) |
0.59 |
Rv0032; Rv0291; Rv0479c; Rv0509; Rv0545c; Rv1201c; Rv1650; Rv1836c; Rv1843c; Rv2296; Rv2482c; Rv2869c; Rv3037c; Rv3255c; Rv3579c; Rv3737; Rv3740c; Rv3825c; Rv3909; |
Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). |
| Vinblastine (DB00570;VLB) |
0.59 |
Rv0914c; Rv2196; Rv2398c; Rv3882c; |
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. |
| Spironolactone (DB00421;SNL) |
0.59 |
Rv0732; Rv0914c; Rv1181.4; Rv1795; Rv2113; Rv2196; Rv2398c; Rv3801c; Rv3825c; Rv3882c; |
Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome. |
| Colchicin (DB01394;LOC) |
0.57 |
Rv0032; Rv0474; Rv0570; Rv0732; Rv1181; Rv1296; Rv1300; Rv1380; Rv1655; Rv2113; Rv2156c; Rv2178c; Rv2281; Rv2524c; Rv3037c; Rv3712; Rv3882c; Rv3886c; |
For treatment and relief of pain in attacks of acute gouty arthritis. |
| Podofilox (DB01179;POD) |
0.56 |
Rv0474; Rv0570; Rv0732; Rv0904c; Rv1181; Rv1296; Rv1300; Rv1550; Rv1650; Rv1795; Rv2113; Rv2156c; Rv2178c; Rv2259; Rv2281; Rv3015c; Rv3037c; Rv3712; Rv3790; Rv3882c; Rv3886c; |
For treatment of external genital warts (Condyloma acuminatum). |
| Lapatinib (DB01259;FMM) |
0.56 |
Rv0237; Rv0511; Rv0527; Rv0545c; Rv0554; Rv0555; Rv0570; Rv0724; Rv0732; Rv0904c; Rv1127c; Rv1181; Rv1220c; Rv1485; Rv1505c; Rv1530; Rv1650; Rv1663; Rv1843c; Rv1872c; Rv1905c; Rv2165c; Rv2231c; Rv2439c; Rv2524c; Rv2610c; Rv2613c; Rv2623; Rv2678c; Rv2897c; Rv2902c; Rv2941; Rv3255c; Rv3405c; Rv3582c; Rv3585; Rv3635; Rv3737; Rv3825c; Rv3871; Rv3882c; Rv3886c; Rv3887c; |
Indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma. |
| Imatinib (DB00619;STI) |
0.55 |
Rv0120c; Rv0627; Rv0843; Rv0904c; Rv1078; Rv1127c; Rv1237; Rv1287; Rv1293; Rv1409; Rv1459c; Rv1492; Rv1542c; Rv1843c; Rv2153c; Rv2170; Rv2231c; Rv2610c; Rv2613c; Rv2623; Rv2869c; Rv2996c; Rv3132c; |
For the treatment Philadelphia chromosome positive chronic myeloid leukemia (CML) and malignant gastrointestinal stromal tumors (GIST) |
| Bexarotene (DB00307;9RA) |
0.55 |
Rv0755c; Rv1237; Rv1753c; Rv1886c; Rv3804c; |
Used orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. |
| Raloxifene (DB00481;RAL) |
0.54 |
Rv0237; Rv0627; Rv0904c; Rv1204c; Rv1237; Rv1277; Rv1459c; Rv1505c; Rv1650; Rv1653; Rv1663; Rv2026c; Rv2124c; Rv2388c; Rv2439c; Rv2524c; Rv2573; Rv2613c; Rv2678c; Rv2935; Rv2938; Rv2946c; Rv3097c; Rv3132c; Rv3405c; Rv3585; Rv3800c; Rv3804c;Rv3825c |
For the prevention and treatment of osteoporosis in post-menopausal women, as well as prevention and treatment of corticosteroid-induced bone loss. |
| Prednisone (DB00635;PDN) |
0.53 |
Rv0256c; Rv1237; Rv1613; Rv1886c; Rv2900c; Rv3245c; Rv3343c; |
For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis. |
| Erythromycin (DB00199;ERY) |
0.53 |
Rv1181; Rv1257c; Rv1589; Rv2243; Rv3712; Rv3793; Rv3801c; Rv3886c; |
For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae. |
| Progesterone (DB00396;STR) |
0.53 |
Rv0220; Rv0724; Rv1237; Rv1613; Rv1753c; Rv1886c; Rv2900c; Rv2938; Rv3245c; Rv3343c; Rv3801c; Rv3804c; Rv3825c; |
For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency |
| Ivermectin (DB00602;IVM) |
0.53 |
Rv0032; Rv0256c; Rv0291; Rv0527; Rv0545c; Rv0585c; Rv0732; Rv1201c; Rv1385; Rv1613; Rv1714; Rv2113; Rv2938; Rv3255c; Rv3825c; |
For the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite Onchocerca volvulus. Can be used to treat scabies caused by Sarcoptes scabiei. |
