Table 2.

Experimental design for three factors and experimental values of objective variables

Run	X1	X2	X3	Y1	Y2
1	0.75	13	0.41	93.13	13.43
2	0.64	14.73	0.57	91.67	11.13
3	0.64	14.73	0.25	94.75	9.31
4	0.64	11.27	0.57	90.51	19.40
5	0.64	11.27	0.25	96.10	12.29
6	0.5	16	0.41	95.41	16.45
7	0.5	13	0.69	86.01	26.18
8	0.5	13	0.13	90.61	17.22
9	0.5	10	0.41	94.72	15.45
10	0.36	14.73	0.57	90.00	21.41
11	0.36	14.73	0.25	95.49	12.57
12	0.36	11.27	0.57	87.95	29.29
13	0.36	11.27	0.25	95.59	14.53
14	0.25	13	0.41	90.42	20.40
15	0.5	13	0.41	94.51	11.99
16	0.5	13	0.41	96.99	15.30
17	0.5	13	0.41	96.96	14.90
18	0.5	13	0.41	96.16	14.98
19	0.5	13	0.41	95.72	16.50
20	0.5	13	0.41	96.06	13.21

Notes: X₁, weight ratio of cholesterol/soybean lecithin; X₂, weight ratio of total lipids/drug; X₃, weight ratio of triolein/soybean lecithin; Y₁, encapsulation efficiency (%); Y₂, mean particle size (µm).