Table 3. LLC Xenograft Model (50 mg/kg single dose): Efficacy Comparison.
| compound | mean TV ± SD (mm3)a | RTVa | TGI(%)a | Cures(%)b |
|---|---|---|---|---|
| control | 4795 ± 1037 | 35.0 ± 15.6 | 0 | 0 |
| DHA | 4704 ± 1092 | 40.9 ± 9.5 | −16.8 | 0 |
| 4armPEG40K-DHA | 1254 ± 327 | 11.5 ± 3.0 | 67.1 | 33.3 |
| 8armPEG20K-DHA | 907 ± 315 | 7.2 ± 2.5 | 79.4 | 50.0 |
| 8armPEG40K-DHA | 648 ± 248 | 6.0 ± 2.3 | 82.8 | 83.3 |
aMean tumor volume (TV), RTV, and % TGI data were taken at day 20. (By day 20, a significant percentage of control animals were euthanized due to excess tumor burden.)
b% cures were taken at day 24.