Table 1.
EMA-CO with high dose methotrexate regimen.
| Time pointsa | Day 1 | Day 2 | Day 8 |
|---|---|---|---|
| Chemotherapy agents | Actinomycin 0.5 mg IV bolus | Actinomycin 0.5 mg IV bolus | Vincristine 1.0 mg/m2 IV bolus |
| Etoposide 100 mg/m2 IV infusion (30 min) | Etoposide 100 mg/m2 IV infusion (30 min) | Cyclophosphamide 600 mg/m2 IV infusion | |
| Methotrexate 1000 mg/m2 IV infusion (24 h) | Leucovorin calcium 15 mg orally every 8 h for nine doses starting 32 h after start of methotrexate |
IV = intravenous.
a
Schedule is based on fourteen-day cycles.