Fig 3. Successive refinements of the shortest-paths sub-networks associated to cell adhesion and motility.

Evolution of the sub-network for the effect of Syk on proteins associated to cell adhesion and motility, starting with unweighted shortest paths, after the integration of weights (A), and by refining them using random walks (B). White nodes correspond to target proteins, grey nodes are intermediate proteins preserved by the refinement. The other colors denote nodes and edges that are affected by the refinement: blue elements are lost, while orange ones are introduced. The shape of nodes symbolizes the identification of the corresponding proteins in the original dataset, as in Fig 2. The ezrin and the cortactin sub-networks illustrated in Fig 2 are included in the adhesion and motility network.