Fig 4. Extension of the weighted shortest-paths sub-networks.

Evolution of the sub-network for the effect of Syk on proteins associated to cell adhesion and motility using weighted shortest paths, and after refinement with random walks, both allowing a 20% overflow. White nodes correspond to target proteins (which are all involved in cell adhesion or motility), grey nodes are intermediate proteins selected with the two approaches. The other colors denote nodes and edges that are specifically selected in one of the two methods: blue for weighted shortest paths, orange with random walk. The shape of nodes symbolizes the identification of the corresponding proteins in the original dataset, as in Fig 2. Although the new paths introduced by the overflow lie outside the cortactin and ezrin sub-networks, this methodological figure is useful for illustrating the flexibility of our approach.