Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 9;254(3):1151–1162. doi: 10.1007/s00709-016-1058-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 2 — Organization of DNA replication from the genome to the individual replisome/replicon. A fluorescently labeled human HeLa Kyoto cell with a typical late S-phase replication pattern is presented in the top left corner (scale bar = 5 μm). Magnified super-resolution replication foci, with white circles representing individual replication sites displayed in the middle of the top row. A scheme of clustered DNA loops with active replication sites (white) is shown on the right. Starting point of DNA replication, the replication origin (ori), and the region replicated from a single origin displayed in the bottom row. Each replicon is replicated by two replication machineries (magenta), composed of various replication proteins, magnified in the bottom left corner. Adapted from (Chagin et al. 2016; Chagin et al. 2010)