Fig. 2.

Visual predictive check of the final Multistate Tuberculosis Pharmacometric model applied to colony forming unit (CFU) data from an acute tuberculosis mouse model. In the left-side figures, no drug treatment (natural growth) was given and, in the right-side figures, rifampicin 30 mg·kg⁻¹·day⁻¹ (the only dose level with longitudinal observations) was given. The upper and lower figures are from data above and below the lower limit of quantification (LLOQ). In the upper figures, the solid black line is the median of the observations. The horizontal solid grey line indicates the LLOQ of the CFU data. Open circles represent the observations. The grey shaded areas represent the 95% confidence intervals for the median of the data simulated by the final model. In the lower plots, the black solid line is the median of the data below the LLOQ. The grey shaded area is the 95% confidence interval for the median of the data below the LLOQ. There were no data below the LLOQ for the natural growth experiments