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. 2017 Mar 16;2017:5642708. doi: 10.1155/2017/5642708

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Copyright © 2017 Tsung-Jung Ho et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of electroacupuncture intervention at various acupoints on the spontaneous motor activity and methamphetamine- (METH-) induced behavioral sensitization. Mice were given saline or METH (2 mg/kg) intraperitoneally for 5 days. EA was applied from withdrawal days 3 to 5. The behavioral sensitization was induced using 1 mg/kg METH at withdrawal day 6. The bar graphs illustrate the cumulative distances of locomotor activity for a 1 h observation period. Spontaneous motor activity: (a) Zusanli (ST36)–Taichong (LR3), (b) Neiguan (PC6)–Quchi (LI11), and (c) Zhubin (KI9)–Taichong (LR3) and METH-induced behavioral sensitization: (d) ST36–LR3, (e) PC6–LI11, and (f) KI9–LR3. All data are expressed as means ± SEMs (n = 4–12 per group). ^∗∗P < 0.01 and ^∗∗∗P < 0.001 versus the Saline-Saline-Sham group; ^###P < 0.001 versus the Saline-METH-Sham group; ⁺⁺P < 0.01 versus METH-METH-Sham group (one-way ANOVA).