Table 3.
Serum biochemistry parameters of control and ELTA treated mice by gavage consecutively for 28 days. Data are expressed as means ± SD (n = 5) and analyzed by one-way ANOVA (∗p < 0.05 versus control). GLU = blood glucose; TG = triglyceride; TCHO = total cholesterol; AST = aspartate aminotransferase; ALT = alanine aminotransferase; CRE = creatinine.
| Sex | Biochemistry parameters | Control | ELTA dose | ||
|---|---|---|---|---|---|
| 150 mg·kg−1 BW | 300 mg·kg−1 BW | 600 mg·kg−1 BW | |||
| Male | GLU (mmol/L) | 10.28 ± 1.34 | 10.04 ± 0.65 | 9.84 ± 1.18 | 9.67 ± 0.84 |
| TG (mmol/L) | 0.76 ± 0.10 | 0.69 ± 0.07 | 0.71 ± 0.06 | 0.65 ± 0.12 | |
| TCHO (mmol/L) | 3.58 ± 0.25 | 3.10 ± 0.17 | 3.15 ± 0.22 | 3.21 ± 0.15 | |
| AST (U/L) | 115 ± 11 | 113 ± 18 | 97 ± 13 | 92 ± 12∗ | |
| ALT (U/L) | 42 ± 6 | 40 ± 5 | 36 ± 4 | 32 ± 4∗ | |
| CRE (μmol/L) | 18.7 ± 2.1 | 15.4 ± 1.7 | 16.3 ± 2.5 | 16.8 ± 2.6 | |
| Sodium (mmol/L) | 146.4 ± 3.2 | 153.7 ± 2.3∗ | 146.6 ± 2.5 | 152.3 ± 1.9∗ | |
| Potassium (mmol/L) | 5.52 ± 0.41 | 6.34 ± 0.69 | 6.52 ± 0.32∗ | 5.97 ± 0.41 | |
| Chloride (mmol/L) | 104.6 ± 4.5 | 98.6 ± 6.3 | 101.1 ± 3.2 | 97.6 ± 5.1 | |
|
| |||||
| Female | GLU (mmol/L) | 10.78 ± 0.74 | 10.35 ± 0.45 | 10.23 ± 0.98 | 9.58 ± 0.56 |
| TG (mmol/L) | 0.84 ± 0.08 | 0.72 ± 0.11 | 0.67 ± 0.12 | 0.63 ± 0.16∗ | |
| TCHO (mmol/L) | 3.81 ± 0.22 | 3.34 ± 0.23 | 3.45 ± 0.27 | 3.12 ± 0.22∗ | |
| AST (U/L) | 112 ± 15 | 104 ± 13 | 108 ± 17 | 95 ± 8∗ | |
| ALT (U/L) | 27 ± 5 | 31 ± 5 | 24 ± 6 | 25 ± 3 | |
| CRE (μmol/L) | 16.3 ± 2.4 | 14.6 ± 1.4 | 15.4 ± 2.0 | 15.7 ± 1.9 | |
| Sodium (mmol/L) | 147.5 ± 1.2 | 147.2 ± 1.1 | 152.6 ± 0.8∗ | 148.4 ± 1.3 | |
| Potassium (mmol/L) | 6.02 ± 0.31 | 7.24 ± 0.45∗ | 6.33 ± 0.25 | 6.71 ± 0.21 | |
| Chloride (mmol/L) | 103.31 ± 3.52 | 105.77 ± 4.34 | 105.24 ± 2.64 | 104.38 ± 2.14 | |