Table 4.
Hematological parameters of control and ELTA treated mice by gavage consecutively for 28 days. Data are expressed as means ± SD (n = 5) and analyzed by one-way ANOVA (∗p < 0.05 versus control). RBC = red blood cells; WBC = white blood cells; HGB = hemoglobin; HCT = hematocrit; MCV = mean corpuscular volume; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; PLT = platelets; LYM = lymphocytes; MONO = monocytes.
| Sex | Hematological parameters | Control | ELTA dose | ||
|---|---|---|---|---|---|
| 150 mg·kg−1 BW | 300 mg·kg−1 BW | 600 mg·kg−1 BW | |||
| Male | RBC (1012/L) | 7.58 ± 1.43 | 7.95 ± 0.84 | 8.14 ± 1.51 | 7.83 ± 0.94 |
| WBC (109/L) | 7.36 ± 0.93 | 8.96 ± 0.53∗ | 6.71 ± 1.21 | 6.96 ± 1.33 | |
| HGB (g/L) | 142 ± 15 | 127 ± 8 | 137 ± 19 | 135 ± 13 | |
| HCT (%) | 47.9 ± 5.4 | 51.3 ± 3.2 | 46.5 ± 3.9 | 48.7 ± 4.1 | |
| MCV (fL) | 51.6 ± 1.8 | 43.8 ± 1.3∗ | 52.3 ± 1.7 | 43.5 ± 1.6∗ | |
| MCH (pg) | 15.8 ± 0.6 | 15.3 ± 0.3 | 15.5 ± 0.7 | 13.8 ± 0.4∗ | |
| MCHC (g/dL) | 29.7 ± 1.5 | 30.4 ± 0.7 | 33.5 ± 0.6∗ | 31.4 ± 0.7 | |
| PLT (109/L) | 657 ± 57 | 586 ± 94 | 614 ± 73 | 627 ± 61 | |
| LYM (%) | 76.2 ± 3.3 | 80.0 ± 4.1 | 78.7 ± 2.5 | 81.3 ± 2.8 | |
| MONO (%) | 2.64 ± 0.57 | 1.86 ± 0.62 | 2.48 ± 0.47 | 2.34 ± 0.35 | |
|
| |||||
| Female | RBC (1012/L) | 7.38 ± 1.17 | 7.27 ± 0.76 | 7.64 ± 1.35 | 6.83 ± 1.24 |
| WBC (109/L) | 7.41 ± 1.23 | 7.26 ± 0.93 | 7.17 ± 0.70 | 7.57 ± 0.32 | |
| HGB (g/L) | 130 ± 13 | 119 ± 10 | 122 ± 9 | 115 ± 14 | |
| HCT (%) | 45.4 ± 3.1 | 46.9 ± 2.8 | 47.8 ± 4.0 | 43.2 ± 4.3 | |
| MCV (fL) | 54.4 ± 1.2 | 55.3 ± 1.0 | 52.9 ± 0.9 | 44.2 ± 1.3∗ | |
| MCH (pg) | 16.2 ± 0.7 | 17.3 ± 0.5 | 16.8 ± 0.6 | 15.4 ± 0.7 | |
| MCHC (g/dL) | 30.6 ± 1.6 | 35.2 ± 0.7∗ | 29.7 ± 1.6 | 33.2 ± 0.8 | |
| PLT (109/L) | 637 ± 53 | 657 ± 49 | 594 ± 37 | 627 ± 45 | |
| LYM (%) | 77.9 ± 3.7 | 78.3 ± 5.6 | 73.5 ± 6.1 | 72.4 ± 3.5 | |
| MONO (%) | 2.56 ± 0.38 | 2.86 ± 0.31 | 2.38 ± 0.17 | 2.75 ± 0.28 | |