Table 2.
Population pharmacokinetic parameter estimates, interindividual variability, and median parameter values (2.5–97.5%) of the nonparametric bootstrap replicates of the final pharmacokinetic model of propofol.
| Parameters | Estimates (RSE, %) | CV (%) | Median (2.5–97.5%) | |
|---|---|---|---|---|
| V1 (L) = θ1 × (LBM/48) | θ 1 | 17.5 (6.6) | 32.9 | 17.4 (15.3–19.8) |
| V2 (L) | 96.3 (5.9) | — | 96.5 (84.4–108) | |
| V3 (L) | 1460 (3.2) | — | 1430 (1015–1500) | |
| Cl (L/min) | 1.13 (3.7) | 19.4 | 1.15 (1.06–1.28) | |
| Q1 (L/min) | 1.03 (4.6) | — | 1.035 (0.944–1.13) | |
| Q2 (L/min) | 0.894 (4.2) | 18.1 | 0.878 (0.789–0.955) | |
| σ | 0.0912 (6.5) | — | 0.091 (0.079–0.102) |
A log-normal distribution of interindividual random variability was assumed. Residual random variability was modeled using constant CV error model. Nonparametric bootstrap analysis was repeated 1,000 times. RSE: relative standard error = SE/mean × 100 (%). LBM: lean body mass calculated using the Janmahasatian formula [31]. V1: central volume of distribution (Vd), V2: rapid peripheral Vd, V3: slow peripheral Vd, Cl: metabolic clearance, Q1: intercompartmental clearance between central and rapid peripheral compartments, and Q2: intercompartmental clearance between central and slow peripheral compartments.