Table 3.
SIRTs regulated by miRNAs.
| SIRTs | Location | Enzymatic activity | miRNAs that targets SIRTs | References |
|---|---|---|---|---|
| SIRT1 | Nucleus, cytosol | Lysine deacetyalase | miR-9 | [21,104–116] |
| miR-34a | ||||
| miR-132 | ||||
| miR-143 | ||||
| miR-146 | ||||
| miR-181a | ||||
| miR-195 | ||||
| miR-217 | ||||
| miR-486-5p | ||||
| SIRT2 | Nucleus, cytosol | Lysine deacetyalase | miR-339 | [117] |
| SIRT3 | Mitochondria, nucleus | Lysine deacetyalase | miR-28-5p | [118] |
| SIRT4 | Mitochondria | ADP-ribosyltransferase | ||
| SIRT5 | Mitochondria | Succinyltransferase, malonyltransferase | ||
| SIRT6 | Nucleus | Demyristoylase, depalmitoylase, ADP-ribosyltransferase, deacetylase | miR-33a | [119–121] |
| miR-34a | ||||
| miR-766 | ||||
| SIRT7 | Nucleus | ADP-ribosyltransferase, deacetylase | miR-93 | [122–123] |
| miR-125a | ||||
| miR-125b |