Table 4.
SIRTs targets involved in metabolism alteration.
| SIRTs | Deacetylation targets | Signaling/metabolic pathways | References |
|---|---|---|---|
| SIRT1 | PGC-1α | Fatty acid oxidation | [93,126–139] |
| LKB1 | Gluconeogenesis | ||
| PGAM-1 | Glycolysis | ||
| PPAR-α | Cholesterol metabolism | ||
| SREBP | AMPK pathway | ||
| FXR | Apoptosis | ||
| Oxysterol receptor | Akt/PI3K signaling | ||
| FOXO | |||
| P53 | |||
| Akt | |||
| SIRT2 | PGC-1α | Fatty acid oxidation | [153–154] |
| SIRT3 | HMGCS2 | Lipid utilization | [140–152] |
| LCAD | Fatty acid oxidation | ||
| AceCS2 | Glucose oxidation | ||
| PDH | TCA cycle | ||
| IDH2 | Oxidation phosphorylation | ||
| GDH | |||
| NDUFA9 | |||
| SDH | |||
| OSCP | |||
| ATP synthase β subunit | |||
| SIRT4 | GDH | Fatty acid oxidation | [92] |
| SIRT5 | HMGCS2 | Lipid utilization | [155] |
| SIRT6 | c-jun | IGF/Akt signaling | [101–102,156–161] |
| PGC-1α | Glycolysis | ||
| H1F1-α | Lipogenesis | ||
| ACC1 | Triglyceride metabolism | ||
| SCD1 | Cholesterol metabolism | ||
| Bcl2 | AMPK pathway | ||
| NFkB | |||
| SIRT7 | TR4/TAK1 | Lipid metabolism | [103,162] |
PGC-1α: PPAR coactivator 1α; LKB1: liver kinase B1; PGAM-1: phosphoglycerate mutase-1; PPAR: peroxisome proliferator-activated receptor; SREBP: sterol regulatory element binding protein; FXR: farnesoid X receptor; FOXO: Forkhead Box Class O; LCAD: long-chain acyl CoA dehydrogenase; HMGCS: 3-hydroxy-3-methylglutaryl-coenzyme A synthase; AceCS2: acetyl-CoA synthase 2; PDH: pyruvate dehydrogenases; IDH2: Isocitrate dehydrogenase 2; GDH: glutamate dehydrogenase; SDH: succinate dehydrogenase; OSCP: oligomycin sensitivity conferring protein; HIF1-α: hypoxia-inducible factor 1α; ACC1: acetyl-CoA carboxylase 1; SCD1: stearoyl-CoA desaturase 1; Bcl2: B-cell lymphoma 2; NFkB: nuclear factor kappa-light-chain-enhancer of activated B cells; TR4/TAK1: testicular receptor 4/transforming growth factor-β-activated kinase.