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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Contraception. 2016 Dec 30;95(4):398–404. doi: 10.1016/j.contraception.2016.12.007

Table 1. Oral contraceptive LNG pharmacokinetic parameter estimates of single-dose vs. steady-state (n = 14).

Parametera Single-dose 1 Single-dose 2b Steady-statec Notes
AUC0-24, ng h/Ml 14.8 (10.1, 21.8) ———— 59.4 (43.5, 81.1) AUC from t0–t24 using 13 measurements: geometric mean ± standard deviation
AUC0-inf, ng h/mL 29.9 (16.3, 54.9) ———— ———— AUC from t0-tinf using 13 measurements: geometric mean ± standard deviation
AUC0-4-24, ng h/mL 18.9 (11.9, 30.2) 18.2 (12.8, 25.9) 66.1 (49.8, 87.8) AUC from t0–t24 using 9 measurements: geometric mean ± standard deviation
Cmax, ng/mL 2.1 (1.4, 3.3) 2.0 (1.3, 3.2) 5.0 (3.8, 6.6) Maximum LNG concentration: geometric mean ± standard deviation
Time at Cmax, h 1.75 (1, 3) 1.5 (1, 4) 1.5 (1, 2.5) Time at maximum concentration: median and interquartile range
Elimination half-life, h 27.2 (15.8, 47.1) ———— 43.1 (16.8, 110.9) Elimination half-life calculated using concentrations at 12, 16, and 24 hours: geometric mean ± standard deviation
C24, ng/mL at t24 0.3X (0.2X, 0.6X) 0.3X (0.2X, 0.5X) 1.75 (1.1X, 2.8X) Concentration at 24 hours: geometric mean ± standard deviation