Table 1.

a: Frequency by type of fold at 3 and 6 months in treated and placebo groups
Peripapillary Wrinkles			ACZ (n=44)		Placebo (n=43)
	Baseline	28	(63.6%)	12	(27.9%)
	3 months	28	(63.6%)*	15	(34.9%)
	6 months	24	(54.5%)**	17	(39.5%)
Retinal folds	Baseline	21	(47.7%)	23	(53.5%)
	3 months	12	(27.3%)***	22	(51.2%)
	6 months	9	(20.5%)+,****	22	(51.2%)
Choroidal folds	Baseline	7	(15.9%)	3	(7%)
	3 months	3	(3.8%)	2	(4.7%)
	6 months	3	(3.8%)++	2	(4.7%)

b. Change in Folds at 3 and 6 months by type and treatment group
	Peripapillary Wrinkles						Retinal folds						Choroidal folds
	resolved		No change		New folds		resolved		No change		New folds		resolved		No change		New folds
ACZ (n=44)	n		n		n		n		n		n		n		n		n
3 months	5	11%	29	66%	10	23%	10	23%	33	75%	1	2%	5	11%	38	86%	1	2%
6 months	7	16%	34	77%	3	7%	11	25%	33	75%	0	0%	5	11%	37	84%	2	5%
Placebo (n=43)
3 months	3	7%	34	79%	6	14%	7	16%	30	70%	6	14%	4	9%	38	88%	1	2%
6 months	3	7%	32	74%	8	19%	9	21%	26	60%	8	19%	2	5%	40	93%	1	2%

n is the number of eyes in each group

Comparison between ACZ and Placebo groups:

^*p=0.001;

^**p=0.007;

^***p=0.019;

^****p=0.003

Change from baseline for ACZ group:

⁺p=0.001;

⁺⁺p=0.032

No other values significant difference between treatment groups or change over time