Table 2.

Change from presentation for optic nerve head (ONH) shape, retinal nerve fiber layer (RNFL) thickness, optic nerve head volume and Frisėn grade grouped by the change in peripapillary wrinkles (PPW), retinal folds (RF), and choroidal folds (CF) at six months – with Bonferonni correction. For optic nerve head shape (eigenvalue of the second principal component) change, minus is used for posterior direction movement away from the vitreous for the retinal pigment epithelium/Bruch’s membrane neural canal border. For retinal nerve fiber layer thickness (µm), optic nerve head volume (mm³), and Frisėn grade change positive is for less thickness or swelling.

Papilledema feature change	Fold change	PPW N	Mean	Std. Dev.	95% CI	P value between groups comparison	RF N	Mean	Std. Dev.	95% CI	P value between groups Compariso n	CF N	Mean	Std. Dev.	95% CI	P value between groups comparison
ONH Shape	Resolved	19	−0.13	1.58	−0.94, 1.58	1.0	20	−.66	1.70	−1.48, .16	.34	6	−1.02	1.1	−2.2, 0.2	0.38
	No change	46	0.09	1.96	−.54, 1.96		57	.13	1.91	−.40, .67		77	.044	1.9	−.04, 0.5
	New folds	19	−.04	1.89	−.95, 1.89		8	.51	1.71	−1.07, 2.09		2	.497	.26	−1.8, 2.8
RNFL Thickness	Resolved	19	222	206	123, 206	.16	20	218	196	126, 310	.021	6	188	201	2, 374	0.58
	No change	43	83	137	38, 137		54	105	143	65, 146		74	120	160	81, 158
	New folds	19	122	132	59, 132		8	20	57	−33, 80		2	141	145	−1161, 1443
ONH volume	resolved	18	5.91	4.33	3.8, 4.3	.07	20	5.64	4.32	3.6, 7.7	.011	6	5.87	4	2.2, 9.6	0.81
	No change	43	2.34	3.21	1.3, 3.2		53	2.94	3.14	2, 3.8		73	3.18	3.6	2.3, 4.0
	New folds	19	3.29	2.88	1.9, 2.9		8	.57	1.32	−.6, 1.8		2	3.10	3.6	−29.7, 35.9
Frisén Grade	resolved	17	1.3	1.1	0.7, 1.1	.07	19	1.2	1.1	0.6, 1.7	.020	6	1.6	1.3	0.4, 2.7	.061
	No change	45	0.5	1.0	0.2, 1.0		54	0.6	1.0	0.4, 0.9		74	.6	0.96	0.4, 0.9
	New folds	19	0.5	0.8	0.2, 0.8		19	0	0.5	−0.4, 0.4		2	0	1.4	−3.5, 0.4

Note that for both resolved and worse change of the peripapillary wrinkles, the retinal nerve fiber layer thickness, optic nerve head volume and Frisėn are less swollen or decreased. N is the number of study eyes with the specific type of fold. Std. dev. is the standard deviation. The confidence interval (CI) is the 95^th percentile.