Table 3.

Summary of the neighbor-neighbor axes.

Axes	Signals	Comments	Sources
FB—BrA	Upd2, JAK-STAT, Dilps	Organismal growth, metabolism	Rajan and Perrimon, 2012
FB—OvA	TOR, GCN2	Reproduction	Armstrong et al., 2014
He—FBA	JNK, Upd3, JAK-STAT	–	Chakrabarti et al., 2016
FB—BrA	Dilp2, 5, 6	Lifespan	Bai et al., 2012
Br—FBA	Dmp53, Dilp2	Lifespan	Bauer et al., 2007
Br—FBA	JNK, Dilp2	Stress response	Karpac et al., 2009
Br—OvA	Dilp1	Reproduction	Liu et al., 2016
Br—OvA	Dilps	Reproduction	LaFever and Drummond-Barbosa, 2005
Br—OvA	dendos	Reproduction	Drummond-Barbosa and Spradling, 2004
Br—BMA	AMPK	Muscle homeostasis	Ulgherait et al., 2014
Br—OvA	Dilps	Reproduction	Ikeya et al., 2002
BM—Re, Br, FBA	FOXO, 4E-BP, Insulin	Proteostasis	Demontis and Perrimon, 2010
EN—ITL	PDF, Dilp7, Dilp2,3,5	Tissue growth	Linneweber et al., 2014
FB—BrL	TORC1, Dilps	Metabolism	Géminard et al., 2009
FB—BrL	dMyc, Dilp2	Organismal growth	Parisi et al., 2013
FB—BrL	mitogen	CNS	Britton and Edgar, 1998
FB—BrL	Slif, InR, PI3K/TOR	CNS	Sousa-Nunes et al., 2011
Br—FBL	sNPF, SNPFR1, Dilp2	Organismal growth, metabolism	Lee et al., 2008
Br—POL	SDR, Dilps, Insulin/IGF	Tissue growth	Okamoto et al., 2013
FB, Br—LGL	Dilp2, InR-dTOR-wg	Hematopoiesis	Shim et al., 2012
FB—SGL	Slif, TSC/TOR, PI3	Tissue growth	Colombani et al., 2003
BM—SG, FBL	InR, Foxo, dMyc	Tissue growth	Demontis and Perrimon, 2009
Br—PGL	Imp-L2, IIS	Development	Sarraf-Zadeh et al., 2013
He—BML	Upd2, Upd3	Immune response	Yang et al., 2015
CA—PGL	JH, Insulin, ecdysone	Development, organismal growth	Mirth et al., 2014
FB—BrL	Eiger, TACE, Grnd	Organismal growth	Agrawal et al., 2016
FB—HtL	TOR	Heart structure, function	Birse et al., 2010
BM—FBL	Imp-L2	Lifespan	Owusu-Ansah et al., 2013

FB, fat body; Br, brain; Ov, ovary; He, hemocyte; BM, body muscle; Re, retina; IT, intestinal trachea; EN, enteric neuron; PO, peripheral organ; LG, lymph gland; SG, salivary gland; PG, prothoracic gland; CA, corpora allata; Ht, heart; A, adults; L, larvae.