Table 4.
Description of the principle background for the calculation of crude cost and cost-efficiency by scenario.
| Cost calculation | |||||
|---|---|---|---|---|---|
| Scenario | Cost composition | Calculation basis 2012 | Calculation basis 2013 | Calculation basis 2014 | Calculation 2015 onward |
| 1 | Post-exposure prophylaxis (PEP) | Number of recommended PEP registered June to December 12, extrapolated to 12 months | Number of recommended PEP registered June to December 2012, extrapolated to 12 months | Number of recommended PEP registered June to December 2012, extrapolated to 12 months | Number of recommended PEP registered June to December 2012, extrapolated to 12 months |
| 2 | PEP and vaccination | number of recommended PEP registered in 2012 | number of recommended PEP registered in 2013 | number of recommended PEP in 2014 | mean number of recommended PEP registered in 2013 and 2014 |
| Cost of vaccination campaign in 2012 | Cost of vaccination campaign in 2013 | Estimated yearly flat rate for reintroduction control and small scale emergency vaccination | Estimated yearly flat rate for reintroduction control and small scale emergency vaccination | ||
| 3 | PEP and vaccination | Sum of high risk exposures and 30% of moderate risk exposures registered June to December 2012, extrapolated to 12 months | Full cost for Essen 5 doses PEP for sum of high risk exposures and cost of three doses for 30% of moderate risk exposures registered in 2013 | Full cost for Essen 5 doses PEP for sum of high risk exposures and cost of three doses for 30% of moderate risk exposures registered in 2014 | Full cost of PEP for mean number of high risk exposures and cost for three doses for 30% of moderate risk exposures registered in 2013 and 2014 |
| Cost of vaccination campaign in 2012 | Cost of vaccination campaign in 2013 | Estimated yearly flat rate for reintroduction control and small scale emergency vaccination | Estimated yearly flat rate for reintroduction control and small scale emergency vaccination | ||
| Cost-effectiveness calculation | |||||
| Scenario | Calculation of exposures averted | Calculation of disability-adjusted life years (DALY) averted | Cumulative cost after 20 years | DALY averted after 20 years | Cost per DALY averted over 20 years |
| 1 | Number of recommended PEP with high and moderate exposure risk background registered in 2012 and extrapolated to the following years | 19% of number of exposures averted multiplied with years of life lost (YLL) according to different age classes | 388,515,250 FCFA/770,038 USD | 6,372 | 60,971 FCFA/121 USD |
| 2 | Difference of extrapolated number of high and moderate risk exposure cases registered in 2012 and effective exposures (100% of high risk and 70% of moderate risk) registered in 2013 and 2014 | 19% of number of exposures averted multiplied with YLL according to different age classes | 349,001,170 FCFA/691,721 USD | 9,055 | 38,544 FCFA/76 USD |
| 3 | Difference of extrapolated number of high and moderate risk exposure cases registered in 2012 and effective exposures (only high risk) registered in 2013 and 2014 | 19% of number of exposures averted multiplied with YLL according to different age classes | 287,226,252 FCFA/569,283 USD | 9,055 | 31,721 FCFA/63 USD |
For all costs, a discount rate of 4% was applied.
Exchange rate 2012 applied, 1 USD = 504.54 FCFA.