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. 2017 Apr 3;10:90. doi: 10.3389/fnmol.2017.00090

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Copyright © 2017 Noristani, Gerber, Sabourin, Le Corre, Lonjon, Mestre-Frances, Hirbec and Perrin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal analyses of de-regulated genes in microglia after 2 severities of SCI. (A–C) Venn diagrams displaying the number of deregulated genes in microglia isolated by flow cytometry at the indicated stages after HS and FT. Relationship between average expression and log 2 of the fold-change in microglia at different stages after HS (D–F) and FT (G–I) injuries. Horizontal blue lines indicate the cut off criterion used to define deferentially expressed genes with a FC >2 (logFC comprised between–1 and 1) and a significant false discovery rate (FDR) values (p < 0.05). Red points indicate significantly deregulated genes following injury. Multidimensional scaling plots displaying distances, in terms of biological coefficient of variation (J) and fold change (K) in microglia at different stages after HS and FT injuries relative to NI control.