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Visualization of β-values of hand, knee and shoulder SFs in the UCSC genome browser showed (a) hypomethylation of the 5′ HOXA-encoded genes in hand versus knee or shoulder SFs and (b) hypomethylation of HOTAIR and HOXC11 loci in hand and shoulder versus knee SF, while genes in the central part of the HOXC cluster mainly showed gene body hypermethylation in joints of the upper extremity.
