Table 1.
Baseline characteristics of 357 patients with febrile urinary tract infection
| Randomized (n = 200) | Not randomized (n = 157) | P valuec | ||
|---|---|---|---|---|
| Antibiotic treatment for 7 days (n = 97) | Antibiotic treatment for 14 days (n = 103) | |||
| Age (years) | 60 (48–72) | 61 (40–73) | 63 (49–75) | 0.277 |
| Male sex | 44 (45%) | 42 (41%) | 58 (37%) | 0.247 |
| Body mass index (kg/m2, mean, SD) | 26.3 (5.2) | 25.8 (4.5) | 26.1 (4.9) | 0.969 |
| Urologic history | ||||
| Indwelling urinary catheter | 3 (3%) | 2 (2%) | 12 (8%) | 0.024 |
| Urinary tract disordera | 28 (29%) | 28 (27%) | 52 (33%) | 0.296 |
| Recurrent UTIb | 19 (20%) | 19/100 (19%) | 47/147 (32%) | 0.007 |
| Comorbidity | ||||
| Diabetes mellitus | 12 (12%) | 17 (17%) | 25 (16%) | 0.709 |
| Malignancy | 3 (3%) | 5 (5%) | 17 (11%) | 0.012 |
| Heart failure | 12 (12%) | 6 (6%) | 19 (12%) | 0.340 |
| Cerebrovascular disease | 5 (5%) | 5 (5%) | 13 (8%) | 0.210 |
| Chronic renal insufficiency | 3 (3%) | 2 (2%) | 10 (6%) | 0.070 |
| COPD | 10 (10%) | 11 (11%) | 23 (15%) | 0.236 |
| Immunocompromised | 3 (3%) | 8 (8%) | 14 (9%) | 0.209 |
| Signs and symptoms at presentation | ||||
| Presentation at emergency department | 59 (61%) | 68 (66%) | 145 (92%) | <0.001 |
| Antibiotic pretreatment | 23 (24%) | 29 (28%) | 56 (36%) | 0.048 |
| Fever duration, hours | 30 (15–48) | 36 (20–60) | 48 (19–96) | 0.081 |
| Dysuria | 82/95 (86%) | 78/102 (77%) | 102/145 (70%) | 0.019 |
| Flank pain | 57/96 (59%) | 67/102 (66%) | 91/144 (63%) | 0.914 |
| Suprapubic pain | 51/96 (53%) | 48/100 (48%) | 72/145 (50%) | 0.876 |
| Perineal pain | 4/96 (4%) | 7/98 (7%) | 8/140 (6%) | 0.986 |
| Shaking chills within previous 24 hours | 63/97 (65%) | 60/101 (59%) | 102/149 (70%) | 0.256 |
| Temperature > 38 °C | 66 (68%) | 76 (74%) | 121 (77%) | 0.226 |
| Systolic blood pressure (mm Hg, mean, SD) | 132 (19) | 132 (22) | 129 (20) | 0.324 |
| Pulse rate (beats/minute) | 93 (17) | 94 (19) | 97 (19) | 0.360 |
| Outpatient treatment | 45 (46%) | 45 (44%) | 23 (15%) | <0.001 |
| Positive urine culture | 69 (71%) | 68 (66%) | 107 (68%) | 0.944 |
| Positive blood culture | 20/88 (23%) | 15/98 (15%) | 45/153 (29%) | 0.012 |
| Positive urine and/or blood culture | 75 (77%) | 70 (68%) | 118 (75%) | 0.571 |
| Initial intravenous dose(s) of antibiotics | 48 (50%) | 55 (53%) | 133 (85%) | < 0.001 |
Data presented as number (%) or median (IQR)
COPD chronic obstructive pulmonary disease, UTI urinary tract infection
aAny functional or anatomical abnormality of urinary tract except urinary catheter
bThree or more UTIs in past 12 months or two or more UTIs in past 6 months
cRandomized (both 7 and 14 days ciprofloxacin) vs. not-randomized patients