Figure 7.

Rho GTPase‐activating protein 1 (Arghap1) downregulates c‐JNKs pathway through inactivation of stress‐induced proteins. External cellular stress induces activation of Ras‐Related C3 Botulinum Toxin Substrate (Rac) and Cell Division Cycle‐42 (CDC42). This triggers the sequential activation of mitogen‐activated protein kinase kinase kinases (MAPKKKs) and mitogen‐activated protein kinase kinases 4/7, resulting in JNKs activation. Arghap1 accelerate the intrinsic GTPase activity of Rac and CDC42 to return it to the inactive GDP‐bound conformation, resulting in downregulation of subsequent pathways. JNKs, Jun N‐terminal kinases.