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. 2017 Feb 27;9(4):448–461. doi: 10.15252/emmm.201606932

Figure 1. The intestinal bacterial flora profile is associated with radiosensitivity in a mouse model.

Figure 1

  • A, B
    The observed species number and Shannon diversity index of intestinal bacteria in male (A) and female (B) mice were examined by 16S high‐throughput sequencing after irradiation at days 5 and 10, n = 4 per group. Statistically significant differences are indicated: Wilcoxon rank sum test. The top and bottom boundaries of each box indicate the 75th and 25th quartile values, respectively, and lines within each box represent the 50th quartile (median) values. Ends of whiskers mark the lowest and highest diversity values in each instance.
  • C, D
    The Shannon diversity index and β‐diversity of intestinal bacteria in male (C) and female (D) mice were examined by 16S high‐throughput sequencing after 6 weeks of antibiotics treatment, n = 4 per group. Statistically significant differences are indicated: Wilcoxon rank sum test. The top and bottom boundaries of each box indicate the 75th and 25th quartile values, respectively, and lines within each box represent the 50th quartile (median) values. Ends of whiskers mark the lowest and highest diversity values in each instance.
  • E, F
    Kaplan–Meier survival analysis of saline‐treated, ampicillin‐treated, and streptomycin‐treated male (E) and female (F) mice after 6.5 Gy TBI were performed (a P < 0.05 by log‐rank test between antibiotic‐treated and saline‐treated groups; b P < 0.005 by log‐rank test between antibiotic‐treated and saline‐treated groups, n = 6 per group).