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. 2017 Feb 27;9(4):448–461. doi: 10.15252/emmm.201606932

Figure 3. FMT ameliorates GI tract function and epithelial integrity after irradiation.

Figure 3

Male mice were separated into two groups after 6.5 Gy gamma ray exposure, where one cohort was treated with saline as a control and the other was treated with sex‐matched FMT.
  • A
    The morphology of the small intestine in the radiation‐induced mice treated with saline or sex‐matched FMT was shown by H&E, AB‐PAS and PAS staining; the small intestine tissues were obtained at day 21 after TBI. The arrows point to the mucus layer or goblet cells.
  • B, C
    Faecal pellet counts removed from cage bedding on 3 day from representative cages is shown. Mean ± SD, n = 6 mice per treatment, ***P < 0.001 by Student's t‐test between Saline + TBI and Male + TBI group.
  • D
    The FITC–dextran in peripheral blood from saline‐treated and sex‐matched FMT mice was assessed at day 21 after irradiation exposure. Mean ± SD. Significant differences are indicated: **P < 0.01; Student's t‐test, n = 6 per group.
  • E–I
    The expression levels of Muc2, Glut1, Pgk1, MDR1 and TFF3 were examined in small intestine tissues from saline‐treated and sex‐matched FMT mice by quantitative PCR; the small intestine tissues were obtained at day 21 after TBI. Mean ± SD. Significant differences are indicated: **P < 0.01; Student's t‐test, n = 12 per group.