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. 2017 Feb 27;9(4):448–461. doi: 10.15252/emmm.201606932

Figure 6. FMT retains the gene expression profile of the small intestine after irradiation.

Figure 6

Male and female mice were separated into two groups after 6.5 Gy gamma ray exposure, where one cohort was treated with saline as control and the other was treated with sex‐matched FMT. Twenty‐one days after irradiation, the mice were euthanized, and the small intestine tissues were excised and microarray analysis was performed.
  • A
    Significantly enriched GO terms (top 30) induced by sex‐matched FMT in male mice. AIRBSRIRBISD, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.
  • B
    Significantly enriched GO terms (top 30) induced by sex‐matched FMT in female mice.
  • C, D
    Heat map of genes significantly up‐ and down‐regulated (red and green, respectively) in small intestine tissue from sex‐matched FMT male mice compared with those of controls. The genes were associated with immunity (C) and metabolism (D), and each row represents a single gene.
  • E, F
    Heat map of genes significantly up‐ and down‐regulated (red and green, respectively) in small intestine tissue from sex‐matched FMT female mice compared with those of controls. The genes were associated with metabolism (E) and immunity (F), and each row represents a single gene.