Figure 2. Microarray analysis of AML xenografts (Xn).

1. Ingenuity Pathway Analysis (IPA) of increased (upper panel) and decreased (lower panel) functions in T5 (5^th generation)‐ versus T1 (1^st generation)‐Xn.
2. Activated (upper panel) and inhibited (lower panel) upstream regulators in T5‐ versus T1‐Xn according to IPA.
3. IPA of the mTOR pathway according to gene expression changes in T5‐ versus T1‐Xn. Red/pink indicates increased gene expression, and green indicates decreased expression. *MTOR demonstrated activation as an upstream regulator with an activation z‐score of 2.615 and a P‐value of 1.93E‐05.
4. Enriched Gene Ontology (GO) biological processes according to differentially expressed genes in T5‐Xn compared to normal human kidneys.