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. 2017 Feb 20;9(4):415–429. doi: 10.15252/emmm.201606937

Figure 2. Blockade of SK4 channels by 1 μM TRAM‐34 reduces arrhythmias recorded in hiPSC‐CMs derived from a CPVT2 (CASQ2‐D307H) patient.

Figure 2

  1. Representative traces of spontaneous APs recorded in a hiPSC‐CM derived from a normal individual under the indicated conditions.
  2. Histograms of statistical data of the beating rate, DD slope, and MDP of hiPSC‐CMs from a normal individual. One‐way ANOVA followed by Tukey's multiple comparison test. For rate (normalized to Control), *P < 0.05, n = 24; for DD slope (normalized to Control), **P < 0.01 and ***P < 0.0001, n = 24; for MDP, ***P < 0.0001, n = 24. Bars and error bars are mean ± SEM.
  3. Representative traces of spontaneous APs recorded in a hiPSC‐CM derived from a CPVT2 patient under the indicated conditions.
  4. Histograms of statistical data of the beating rate, APD50, and DADs of hiPSC‐CMs from a CPVT2 patient. One‐way ANOVA followed by Tukey's multiple comparison test. For the rate, P = ns, n = 21; for the APD50, P = ns, n = 19; for the DADs, **P < 0.01, n = 19. Bars and error bars are mean ± SEM.