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. 2017 Feb 20;9(4):415–429. doi: 10.15252/emmm.201606937

Figure 7. Blockade of SK4 channels by TRAM‐34 improves the ECG arrhythmic features of CASQ2‐D307H KI and CASQ2 KO mice during treadmill exercise.

Figure 7

  1. Representative ECG recording following intraperitoneal injection of vehicle (upper) and 20 mg/kg TRAM‐34 (lower) in WT mice during treadmill exercise.
  2. Data summary of heart rate (paired t‐test; ***P = 0.001, n = 10) and PR interval (paired t‐test; ***P = 0.0005, n = 10) in WT mice during exercise. Error bars: ± SEM.
  3. Representative ECG recording following IP injection of vehicle (upper) and 20 mg/kg TRAM‐34 (lower) in CASQ2‐D307H KI mice during treadmill exercise.
  4. Data summary of heart rate (paired t‐test; ***P = 0.0004, n = 11) and PR interval (paired t‐test; **P = 0.0099, n = 11) in CASQ2‐D307H KI mice during exercise. Error bars: ± SEM.
  5. Representative ECG recording following IP injection of vehicle (upper) and 20 mg/kg TRAM‐34 (lower) in CASQ2 KO mice during treadmill exercise.
  6. Data summary of heart rate (paired t‐test; *P = 0.0165, n = 7) and PR interval (paired t‐test; **P = 0.0042, n = 7) in CASQ2 KO mice during exercise. Error bars: ± SEM.