Table 1.
Improvement of arrhythmogenic features at rest or during exercise in CPVT2 CASQ2‐D307H KI and CASQ2 KO mice after IP injection of the SK4 blockers TRAM‐34 or clotrimazole
| Number of mice (n) | 5 | 5 | 12 | 12 |
|---|---|---|---|---|
| Vehicle | Clotrimazole 20 mg/kg | Vehicle | TRAM‐34 20 mg/kg | |
| KI at rest | ||||
| Normal | 0 | 3 | 3 | 9 |
| VPC | 4 | 2 | 6 | 3 |
| NSVT | 1 | 0 | 3 | 0 |
| SVT | 0 | 0 | 0 | 0 |
| KI during exercise | ||||
| Normal | 0 | 0 | 1 | 4 |
| VPC | 1 | 2 | 2 | 4 |
| NSVT | 4 | 2 | 9 | 4 |
| SVT | 0 | 1 | 0 | 0 |
| Number of mice (n) | 6 | 6 | 6 | 6 |
|---|---|---|---|---|
| Vehicle | Clotrimazole 20 mg/kg | Vehicle | TRAM‐34 20 mg/kg | |
| KO at rest | ||||
| Normal | 0 | 4 | 1 | 6 |
| VPC | 4 | 2 | 5 | 0 |
| NSVT | 2 | 0 | 0 | 0 |
| SVT | 0 | 0 | 0 | 0 |
| KO during exercise | ||||
| Normal | 0 | 0 | 0 | 3 |
| VPC | 0 | 2 | 0 | 0 |
| NSVT | 5 | 3 | 3 | 3 |
| SVT | 1 | 1 | 3 | 0 |
VPC, ventricular premature complexes; NSVT, non‐sustained ventricular tachycardia; SVT, sustained ventricular tachycardia. The types of arrhythmic features were classified following their severity: sinusal rhythm (normal), ventricular premature contractions (VPC), NSVT, and SVT.