[Table/Fig-4]:
Genotype distributions and allele frequencies of VDR gene polymorphisms under study by clinical group.
| SNP id (restriction enzyme) | Clinical groups* | OR (95% CI)† | p-value‡ | ||
|---|---|---|---|---|---|
| Healthy controls (n = 50) |
Chronic periodontitis (n = 110) |
||||
| rs7975232 (ApaI) | |||||
| Genotype | GG | 5 (10.0) | 19 (17.3) | Referent | 0.110 |
| GT | 25 (50.0) | 64 (58.2) | 1.48 (0.50 -4.40) | ||
| TT | 20 (40.0) | 27 (24.5) | 2.82 (0.90 - 8.92) | ||
| Allele frequency | G | 35 (35.0) | 102 (46.4) | Referent | 0.057 |
| T | 65 (65.0) | 118 (53.6) | 1.60 (0.98 – 2.61) | ||
| Hardy-Weinberg equilibrium χ2 critical value | 0.978 | 2.892 | |||
| χ2 test p value | 0.322 | 0.089 | |||
| rs1544410 (BsmI) | |||||
| Genotype | GG | 18 (36.0) | 50 (45.5) | Referent | 0.504 |
| GA | 23 (46.0) | 45 (40.9) | 1.42 (0.68 - 2.97) | ||
| AA | 9 (18.0) | 15 (13.6) | 1.67 (0.62 - 4.47) | ||
| Allele frequency | G | 59 (59.0) | 145 (65.9) | Referent | 0.233 |
| A | 41 (41.0) | 75 (34.1) | 1.34 (0.82 – 2.18) | ||
| Hardy-Weinberg equilibrium χ2 critical value | 0.242 | 0.798 | |||
| χ2 test p value | 0.622 | 0.371 | |||
| rs2228570 (FokI) | |||||
| Genotype | TT | 6 (12.0) | 14 (12.7) | Referent | 0.706 |
| TC | 28 (56.0) | 54 (49.1) | 1.21 (0.42 - 3.49) | ||
| CC | 16 (32.0) | 42 (38.2) | 0.89 (0.29 – 2.71) | ||
| Allele frequency | T | 40 (40.0) | 82 (37.3) | Referent | 0.642 |
| C | 60 (60.0) | 138 (62.7) | 0.89 (0.54 – 1.44) | ||
| Hardy-Weinberg equilibrium χ2 critical value | 2.777 | 0.252 | |||
| χ2 test p value | 0.095 | 0.615 | |||
| rs731236 (TaqI) | |||||
| Genotype | TT | 21 (42.0) | 53 (48.2) | Referent | 0.767 |
| TC | 24 (48.0) | 47 (42.7) | 0.77 (0.38 – 1.57) | ||
| CC | 5 (10.0) | 10 (9.1) | 1.48 (0.24 – 2.59) | ||
| Allele frequency | T | 66 (66.0) | 153 (69.5) | Referent | 0.527 |
| C | 34 (34.0) | 67 (30.5) | 0.85 (0.51 – 1.40) | ||
| Hardy-Weinberg equilibrium χ2 critical value | 0.483 | 0.006 | |||
| χ2 test p value | 0.486 | 0.935 | |||
* Values are given as n (%) of individuals within diagnosis
† Odds ratio (95% confidence interval)
‡ Two-sided Pearson’s chi-square test (χ2)