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. 2017 Mar 2;36(7):919–933. doi: 10.15252/embj.201696241

Figure 6. Comparison of the structures of ZIKV RdRp with other flavivirus RdRps.

Figure 6

  • A–C
    Superimposition of ZIKV RdRp with WNV RdRp (white, PDB: 2HCS) (Malet et al, 2007) (A), DENV3 (gray, PDB: 4HHJ) (Noble et al, 2013) (B), or JEV NS5 (light pink, PDB: 4K6M) (Lu & Gong, 2013) (C). ZIKV RdRp is colored by subdomains. The rotations of the thumbs are observed between the two structures. The variable regions in fingers subdomain are highlighted by dashed cycles and shown in large view. The disordered region in ZIKV RdRp (between M455 and W476) is shown as a dashed line.