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. 2017 Feb 8;36(7):854–868. doi: 10.15252/embj.201696012

Figure 4. The L1 stalk and Nmd3 adopt multiple states.

Figure 4

  • A
    Overlap of the four observed states for L1 stalk/Nmd3. T1 (tan) and T2 (purple) are transition states between the fully open (gray) and fully closed (blue).
  • B
    Rigid‐body docking of uL1‐L1‐Nmd3 into T2 state, showing the atomic model overlap between the closed (orange) and T2 position (blue).
  • C, D
    Model for coordination of Nmd3 action with Sdo1. (C) In the closed conformation of L1 stalk/Nmd3, the eL22‐like domain of Nmd3 occupies the P site where it would clash with domain I of Sdo1. (D) In transition state T2, the clash between Nmd3 and Sdo1 in the P site is greatly reduced, potentially allowing for the accommodation of Sdo1.