Table 1. Characteristics of the included studies.
| First author | Year | Study Year of recruitment | Country | Study design | Age, y | No. of Subjects/cases | Outcome assessment | Markers | CRP measurement methods |
|---|---|---|---|---|---|---|---|---|---|
| Il’yasova | 2005 | HABCS 1997-1998 | USA | Cohort | 73(70-79) | 2438/33 | Pathology reports | CRP | ELISA |
| Siemes | 2006 | Rotterdam 1989-1993 | Netherlands | Cohort | 69.6(9.2) | 3790/184 | Pathology reports | Hs-CRP | Rate Near-infrared Particle Immunoassay |
| Jacquotte | 2007 | NYUWHS | USA | Nested C-C | Not Given | 248/85 | Not Given | CRP | The Behring NA Latex Test |
| Zhang | 2007 | WHS 1992 | USA | Cohort | 54.5 | 274703/892 | Medical records | CRP | Latex-enhanced Immunoturbidimetry |
| Heikkila | 2009 | BWHHS 1999-2001 | British | Cohort | 69.2 | 3274/48 | Cancer registry | Hs-CRP | Ultrasensitive Nephelometry |
| Allin | 2009 | CCHS 1946-1978 | Danish | Cohort | 30-71 | 5561/207 | Cancer registry | Hs-CRP | Turbidimetry or Nephelometry |
| Van Hemelrijck | 2011 | AMORIS 1985-1986 | Sweden | Cohort | 44.8(16.68) | 54248/1241 | Cancer registry | CRP | Turbidimetry |
| Gaudet | 2013 | CPS-II 1998-2001 | USA | Nested C-C | 50-74 | 594/297 | Cancer registry | CRP | ELISA |
| Hong | 2013 | 2008-2011 | China | C-C | 53.7(12.1) | 1012/506 | Medical records | CRP | ELISA |
| Prizment | 2013 | ARIC 1987-1989 | USA | Cohort | 45-64 | 35888/176 | Cancer registry | Hs-CRP | Immunoturbidimetry |
| Ollberding | 2013 | Multiethnic 2001-2006 | USA | Nested C-C | 67.8(7.4) | 1412/706 | Cancer registry | CRP | Turbidimetry |
| Touvier | 2013 | SU.VI.MAX 1994-1995 | France | Nested C-C | 49.2(6.1) | 654/218 | Medical records | Hs-CRP | ELISA |
| Alokail | 2013 | Not Given | KSA | C-C | 46.4(11.3) | 109/56 | Pathology reports | Hs-CRP | ELISA |
| Dossus | 2014 | E3N 1995-1999 | France | Nested C-C | 57.6(6.1) | 1589/549 | Pathology reports | CRP | Particle-enhanced Immunoturbidimetry |
| Wang | 2014 | Kailuan 2006-2011 | China | C-C | 49.2(11.3) | 19437/88 | Pathology reports | Hs-CRP | Nephelometry |
Abbreviations: HABCS, the Health Aging and Body Composition Study; NYUWHS, the New York University Women’s Health Study; WHS, the Women’s Health Study; BWHHS, the British Women’s Heart and Health Study; CCHS, the Copenhagen City Heart Study; AMORIS, the Apolipoprotein MOrtality RISk study; CPS-II, the American Cancer Society’s Cancer Prevention Study-II Nutrition Cohort; ARIC, the Atherosclerosis Risk in Communities Cohort Study; SU.VI.MAX, the Supplémentation en Vitamines et Minéraux Antioxydants Study; E3N, the E3N Cohort Study; CRP, C-reactive protein; Hs-CRP, High-sensitivity C-reactive protein; C-C, case-control; ELISA, enzyme linked immunosorbent assay.