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. 2017 Feb 20;13(4):1285–1294. doi: 10.3892/etm.2017.4134

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effect of sunitinib on the formation of LC3 puncta in PC-3 and LNCaP cells. (A) Fluorescence images obtained from sunitinib-treated and control groups of prostate cancer cells, PC-3 and LNCaP. Cells treated with DMSO were set as control groups, the numbers of LC3 puncta per cell were counted manually. The number of LC3 puncta (green fluorescent) per cell in sunitinib-treated groups increased in a dose dependent manner (magnification, ×630). (B) Limited numbers of punctas were located in control group PC-3 and LNCaP cells. The numbers of LC3 puncta per cell in PC-3 cells of 5, 10 and 20 µM sunitinib-treated groups were 23.29±3.36, 59.74±6.48 and 113.71±7.52, respectively. The numbers of LC3 puncta per cell in LNCaP cells of 5, 10 and 20 µM sunitinib-treated groups were 28.90±6.34, 87.56±6.45 and 198.56±5.33, respectively. Data are presented as means ± standard deviation (n=4). *P<0.05 and **P<0.01, vs. Con. DSMO, dimethyl sulfoxide. LC3, microtubule associated protein 1A/1B-light chain 3; Con, control; DAPI, 4′,6-diamidino-2-phenylindole; DIC, differential interference contrast.