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. 2017 Feb 20;13(4):1285–1294. doi: 10.3892/etm.2017.4134

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Inhibition of autophagy by 3-MA effects on sunitinib-induced cell apoptosis. (A) Flow cytometric analysis indicated inhibition of autophagy by 3-MA (5 µM) increased the rate of apoptosis induced by sunitinib. (B) Percentage of apoptotic cells in control, sunitinib-treated, 3-MA-treated and sunitinib + 3-MA-treated groups in PC-3 and LNCaP cells (C) Following sunitinib treatment, caspase-3 was activated and inhibition of autophagy enhanced the activation of caspase-3. Data in panel (B) represent the mean ± standard deviation of three independent experiments, *P<0.05 and **P<0.01. 3-MA, 3-methyladenine; Con, control.