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ICA effect diagram. ICA is likely to inhibit the differentiation of MSCs into adipocytes by suppressing the expression of PPARγ, C/EBPα and FABP4 mRNA. In addition, ICA may inhibit the production of Notch2 mRNA through the inhibition of N1ICD expression. NICD, Notch intracellular domain; FABP4, fatty acid-binding protein 4; PPARγ, peroxisome proliferator-activated receptor γ; ICA, icarrin; TADE, tetraaminodiphencyl ether; C/EBPα, CCAAT/enhancer binding protein α.
