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Treatment groups.
| Group | Model | Drug | Dose (mg/kg/day) | Dosing period (weeks) | Administration |
|---|---|---|---|---|---|
| Sham | Sham | Water | – | 12 | Oral gavage |
| OVX-NT | OVX | Water | – | 12 | Oral gavage |
| ICA-L | OVX | ICA | 125 | 12 | Oral gavage |
| ICA-M | OVX | ICA | 250 | 12 | Oral gavage |
| ICA-H | OVX | ICA | 500 | 12 | Oral gavage |
| FOS | OVX | Fosamax | 0.514 | 12 | Oral gavage |
OVX, ovariectomized; OVX-NT, OVX-no treatment group; ICA, icariin; ICA-L, low-dose ICA group; ICA-M, medium-dose ICA group; ICA-H, high-dose ICA group; FOS, Fosamax-treated positive control group.
