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. 2017 Apr 3;7:45459. doi: 10.1038/srep45459

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Ultraviolet-visible-near infrared spectra of gold nanorods (AuNRs) before and after functionalization with thiol-terminated polyethylene glycol molecules (mPEG-SH). The inset shows photographic images of hexadecyltrimethylammonium bromide/sodium oleate (CTAB/NaOL) + AuNRs and polyethylene glycol (PEG)-modified AuNRs (PAuNRs). (B) Zeta-potentials of AuNRs with different surface modifications. CTAB/NaOL + AuNRs showed a positive charge; after PEGylation, the surface charge was close to neutral confirming the successful displacement of CTAB/NaOL by PEG molecules. (C) Transmission electron microscopy (TEM) image of monodispersed CTAB/NaOL + AuNRs. The inset shows a high resolution TEM image of AuNRs with a PEG coating. (D) Results of in vitro cytotoxicity assays in which FM3A-Luc cells were incubated with different concentrations of CTAB/NaOL + AuNRs or PAuNRs for 24 h. Data are presented as mean ± SD (n = 3).