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. Author manuscript; available in PMC: 2018 Mar 10.
Published in final edited form as: J Control Release. 2017 Jan 27;249:94–102. doi: 10.1016/j.jconrel.2017.01.030

Figure 8. Improved efficacy of sEPD of anti-PD-1 antibody.

Figure 8

C57BL/6 mice were s.c. transplanted with B16F10 melanoma cells and then treated with sEPD of anti-PD-1 antibody, or i.p. injection of anti-PD-1 antibody or isotope control at the same antibody dose, or i.p. injection of PBS on day 5, 8, and 11. Patches were removed 24 hours later. A. Tumor size was monitored every other day from day 8. B. Days to reach significant difference of tumor sizes between groups and the significant levels. Two-way ANOVA and Bonferroni post-test were used to compare tumor sizes between groups. C–D. Mice were euthanized on day 16. Tumor was dissected and tumor images were shown in C (scale: 1 cm) and tumor weight was shown in D. Student’s t-test was used to compare tumor weight difference between groups. *, p<0.05; **, p<0.01; ***, p<0.001. n=5.