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. 2017 Apr 3;7:45950. doi: 10.1038/srep45950

Figure 4. Protein-protein interaction network of muscle fibre development and function.

Figure 4

Inline graphic” Denote down-regulated proteins, and “Inline graphic” denote upregulated proteins. The Lines “—” indicate that there was an interaction between proteins. Proteins: gys2, glycogen synthase 2; hsd3b7, hydroxy-delta-5-steroid dehydrogenase, 3; sigmar1, sigma non-opioid intracellular receptor 1; cyb5r2, NADH-cytochrome b5 reductase 2; nsdhl, NAD(P)-dependent steroid; cyp20a1, cytochrome P450, family 20, subfamily A, polypeptide 1; cyp2ad3, cytochrome P450 2AD3; idi1, isopentenyl-diphosphate Delta-isomerase 1; ctrb1, chymotrypsin B1 precursor; zgc:101071, acyl-CoA synthetase long-chain family member 1; dip2ba, DIP2 disco-interacting protein 2 homolog B; bdh1, 3-hydroxybutyrate dehydrogenase, type 1; bdb2, RecName: Full = 3-hydroxybutyrate dehydrogenase type 2; acaa1, acetyl-coenzyme A acyltransferase 1; aldh1l1, aldehyde dehydrogenase 1 family, member L1; hao2, hydroxyacid oxidase 2; aldh9a1b, aldehyde dehydrogenase 9 family, member A1b; akr1b1, aldo-ketoreductase family 1, member B1; gpd1b, glycerol-3-phosphate dehydrogenase 1b; gatm, RecName: Full = glycine amidinotransferase, mitochondrial; g6pd, glucose-6-phosphate 1-dehydrogenase; pdha1a. pyruvate dehydrogenase (lipoamide) alpha 1a; pc, pyruvate carboxylase; pcl, pyruvate carboxylase, like; kpnb3, karyopherin (importin) beta 3; slc25a5, solute carrier family 25 alpha, member 5; cct5, chaperonin-containing TCP1, subunit 5; ipo4, PREDICTED: importin-4; ips13, 40 S ribosomal protein S13; psmc3, proteasome (prosome, macropain) 26 S subunit, ATPase, 3; pdia4, protein disulfideisomerase associated 4; prdx6, peroxiredoxin 6; psmg2, Chaperone protein promoting assembly of the 20 S proteasome as part of a heterodimer with psmg1; hspd1, 60 kDa heat shock protein 1; ppih, peptidyl-prolyl cis-trans isomerase H; gstm, glutathione S-transferase M; gstp1, glutathione S-transferase pi 1; hbaa1, haemoglobin alpha adult-1; pah, phenylalanine hydroxylase; hpda, 4-hydroxyphenylpyruvate dioxygenase a; ttc36, tetratricopeptide repeat domain 36; fgg, fibrinogen gamma polypeptide; tln2, PREDICTED: talin-2-like; ctnna1, PREDICTED: catenin alpha-1-like; tnnc1b, troponin C type 1b (slow); zgc:86725, muscle actin type 1; myl10, myosin, light chain 10, regulatory; smyhc1, myosin heavy chain embryonic type 3; neb, novel protein similar to vertebrate nebulin (NEB); mybpc1, myosin-binding protein C, slow-type; myl4, myosin, light chain 4; tuba8l, tubulin, alpha 8 like; zgc:136545, myosin-binding protein C, fast type a; zgc:56585, ENSDARG00000043403, ENSDARG00000009567 are unknown proteins.