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. 2017 Apr 3;7:45861. doi: 10.1038/srep45861

Table 1. Differentially expressed proteins in HepG2 cells after riboflavin deficiency.

UniProtKB ID Protein name Protein description Fold change p-value
electron transport
P27338 AOFB Amine oxidase [flavin-containing] B −6.87 0.0060
P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial −6.30 0.0008
P15559 NQO1 NAD(P)H dehydrogenase [quinone] 1 −5.29 0.0004
P28331 NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial −5.08 0.0004
P52895 AK1C2 Aldo-keto reductase family 1 member C2 2.90 0.0003
O95831 AIFM1 Apoptosis-inducing factor 1, mitochondrial −2.82 0.0004
Q59ED7 Q59ED7 Putative uncharacterized protein −2.82 0.0491
P31040 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial −2.63 0.0054
Q16881 TRXR1 Thioredoxin reductase 1, cytoplasmic 2.48 0.0005
P42330 AK1C3 Aldo-keto reductase family 1 member C3 2.36 0.0011
B4DEA8 cDNA FLJ56425 Highly similar to Very-long-chain specific acyl-CoA dehydrogenase, mitochondrial −2.10 0.0015
oxidation-reduction process
P27338 AOFB Amine oxidase [flavin-containing] B −6.87 0.0060
P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial −6.30 0.0008
P28331 NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial −5.08 0.0004
Q8TE01 DERP12 Dermal papilla derived protein 12 −3.29 0.0001
P52895 AK1C2 Aldo-keto reductase family 1 member C2 2.90 0.0003
O95831 AIFM1 Apoptosis-inducing factor 1, mitochondrial −2.82 0.0004
Q59ED7 Q59ED7 Putative uncharacterized protein −2.82 0.0491
P31040 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial −2.63 0.0054
Q5T4U5 MCAD Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA_a −2.58 0.0324
Q16881 TRXR1 Thioredoxin reductase 1, cytoplasmic 2.48 0.0005
O00469 PLOD2 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 −2.41 0.0144
P42330 AK1C3 Aldo-keto reductase family 1 member C3 2.36 0.0011
Q9BYN0 SRXN1 Sulfiredoxin-1 2.27 0.0100
Q99943 PLCA 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 2.26 0.0184
B4DEA8 cDNA FLJ56425 highly similar to very-long-chain specific acyl-CoA dehydrogenase, mitochondrial −2.10 0.0015
E7EPT4 NDUFV2 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial −2.07 0.0229
Q96HE7 ERO1A ERO1-like protein alpha −2.01 0.0066
lipid metabolic process
P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial −6.30 0.0008
P52895 AK1C2 Aldo-keto reductase family 1 member C2 2.90 0.0003
Q5T4U5 MCAD Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA_a −2.58 0.0324
Q16881 TRXR1 Thioredoxin reductase 1, cytoplasmic 2.48 0.0005
P42330 AK1C3 Aldo-keto reductase family 1 member C3 2.36 0.0011
Q99943 PLCA 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 2.26 0.0184
B4DEA8 cDNA FLJ56425 highly similar to very-long-chain specific acyl-CoA dehydrogenase, mitochondrial −2.10 0.0015
response to endoplasmic reticulum stress
Q96FC9 DDX11 Probable ATP-dependent DNA helicase DDX11 −4.25 0.0024
B4DEA8 cDNA FLJ56425 highly similar to very-long-chain specific acyl-CoA dehydrogenase, mitochondrial −2.10 0.0015
Q9UGP8 SEC63 Translocation protein SEC63 homolog 2.10 0.0262
Q96HE7 ERO1A ERO1-like protein alpha −2.01 0.0066
response to oxidative stress
P52895 AK1C2 Aldo-keto reductase family 1 member C2 2.90 0.0003
P48507 GSH0 Glutamate-cysteine ligase regulatory subunit 2.58 0.0053
P42330 AK1C3 Aldo-keto reductase family 1 member C3 2.36 0.0011
Q9BYN0 SRXN1 Sulfiredoxin-1 2.27 0.0100
tricarboxylic acid cycle
P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial −6.30 0.0008
P31040 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial −2.63 0.0054
oxidative phosphorylation
P28331 NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial −5.08 0.0004
P31040 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial −2.63 0.0054
E7EPT4 NDUFV2 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial −2.07 0.0229
cell proliferation
Q96FC9 DDX11 Probable ATP-dependent DNA helicase DDX11 −4.25 0.0265
P52895 AK1C2 Aldo-keto reductase family 1 member C2 2.90 0.0003
Q6NS36 FTH1 Ferritin −2.60 0.0121
P42330 AK1C3 Aldo-keto reductase family 1 member C3 2.36 0.0011
P56715 RP1 Oxygen-regulated protein 1 −2.31 0.0018
Q6IBB0 IFITM2 IFITM2 protein −2.05 0.0265
cell differentiation
P11532 DMD Dystrophin −3.73 0.0297
P26232 CTNA2 Catenin alpha-2 −2.98 0.0049
P52895 AK1C2 Aldo-keto reductase family 1 member C2 2.90 0.0003
O95831 AIFM1 Apoptosis-inducing factor 1, mitochondrial −2.82 0.0004
P42330 AK1C3 Aldo-keto reductase family 1 member C3 2.36 0.0011
P56715 RP1 Oxygen-regulated protein 1 −2.31 0.0018
O95361 TRI16 Tripartite motif-containing protein 16 2.21 0.0382
Q6IBB0 IFITM2 IFITM2 protein −2.05 0.0265
apoptotic process
P28331 NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial −5.08 0.0004
P52895 AK1C2 Aldo-keto reductase family 1 member C2 2.90 0.0003
O95831 AIFM1 Apoptosis-inducing factor 1, mitochondrial −2.82 0.0004
Q13501 SQSTM1 Sequestosome-1 2.39 0.0043
P42330 AK1C3 Aldo-keto reductase family 1 member C3 2.36 0.0011
chaperone mediated protein folding requiring cofactor
Q96HE7 ERO1A ERO1-like protein alpha −2.01 0.0066
dUTP metabolic process
A0A126LAZ6 U45 U45 −2.21 0.0008
Others
P68431 H31 Histone H3.1 5.43 0.0420
Q96SI9 STRBP Spermatid perinuclear RNA-binding protein −3.96 0.0070
P62273 RPS29 40 S ribosomal protein S29 2.95 0.0364
P20742 PZP Pregnancy zone protein −2.78 0.0028
P11717 IGF2R Cation-independent mannose-6-phosphate receptor −2.34 0.0083
P62314 SMD1 Small nuclear ribonucleoprotein Sm D1 2.26 0.0419
O60825 F262 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 −2.20 0.0124
Q9Y2T2 AP3M1 AP-3 complex subunit mu-1 −2.05 0.0267