Table 1. Pharmacokinetic parameters of EVL in rats after various treatments.
| TreatmentsParameter | EVL alone | EVL + curcumin (50 mg/kg) | EVL+ curcumin (100 mg/kg) |
|---|---|---|---|
| Cmax | 6.0 ± 1.8 | 1.4 ± 0.9 *** (−76.7%) | 1.4 ± 1.2 *** (−76.7%) |
| AUC0−540 | 1637.7 ± 256.8 | 481.8 ± 327.8 *** (−70.6%) | 466.0 ± 330.2 *** (−71.5%) |
| MRT | 207.8 ± 23.8 | 251.2 ± 28.5 | 281.2 ± 37.6 ** (35.3%) |
Data are expressed as the mean ± S.D.
*p <0.05, ** p < 0.01, *** p < 0.001.
Cmax (ng/mL): peak blood concentration.
AUC0−540 (ng·min/mL): area under the blood concentration–time curve from 0 to 540 min.
MRT (min): mean residence time.