Table 1. Solubility of microcrystalline ZPF, mono-ground ZPF and the corresponding physical mixtures (ZPF + CB[7] and ZPF + β-CD) and co-ground dispersions (ZPF−CB[7], ZPF−β-CD) in pure water, SGF and SIF at 37 ± 0.1 °C after 72 h.
| Samples | Solubility (mg/mL) |
||
|---|---|---|---|
| Water | SGF | SIF | |
| Microcrystalline ZPF | 0.018 ± 0.003 | 0.003 ± 0.001 | 2.23 ± 0.132 |
| Mono-ground ZPF | 0.021 ± 0.005 | 0.005 ± 0.001 | 2.37 ± 0.051 |
| Microcrystalline ZPF + CB[7] | 0.023 ± 0.004 | 0.008 ± 0.002 | 1.19 ± 0.035& |
| Microcrystalline ZPF + β-CD | 0.090 ± 0.008* | 0.022 ± 0.004# | 1.45 ± 0.041& |
| Mono-ground ZPF + CB[7] | 0.025 ± 0.005 | 0.009 ± 0.003 | 1.28 ± 0.079& |
| Mono-ground ZPF + β-CD | 0.093 ± 0.007* | 0.022 ± 0.006# | 1.49 ± 0.086& |
| ZPF−CB[7] | 0.076 ± 0.006* | 0.052 ± 0.005# | 1.23 ± 0.082& |
| ZPF−β-CD | 0.101 ± 0.013* | 0.063 ± 0.006# | 1.58 ± 0.051& |
Values are presented as mean ± SD (n = 3), *p < 0.05 compared with microcrystalline ZPF group in water; #p < 0.05 compared with microcrystalline ZPF group in SGF; &p < 0.05 compared with microcrystalline ZPF group in SIF.