Table 2.
Association between CYP2C9 and CYP2C19 genotypes and Prakriti with phenotype.
| Toxic plasma concentrations of phenytoin (N = 351) |
Odds ratio and 95% C.I. | p value | |||
|---|---|---|---|---|---|
| Yes | No | ||||
| CYP2C9 genotype | *1/*1 | 34 | 227 | – | 0.002* |
| *1/*2 | 5 | 34 | 0.98 [0.36,2.68] | ||
| *1/*3 | 17 | 32 | 3.54 [1.78,7.07] | ||
| *3/*3 | 0 | 2 | 2.22[0.22,22.01] | ||
| CYP2C19 genotype | *1/*1 | 17 | 117 | – | 0.33 |
| *1/*2 | 34 | 140 | 1.67[0.89,3.14] | ||
| *2/*2 | 5 | 37 | 0.93[0.32, 2.69] | ||
| *3/*3 | 0 | 1 | 3.44[0.30,40.00] | ||
| Prakriti | KV | 24 | 113 | – | 0.81 |
| KP | 14 | 68 | 0.96[0.46,2.00] | ||
| PK | 2 | 11 | 0.86[0.18,4.11] | ||
| PV | 1 | 14 | 0.34[0.04, 2.68] | ||
| VK | 9 | 64 | 0.66 [0.29,1.51] | ||
| VP | 6 | 25 | 1.13 [0.42, 3.05] | ||
*p < 0.05.